Turmeric and curcumin: the gold of spices

Table of contents

The turmeric plant(Curcuma longa), also known as turmeric, is a central component of Asian cuisine and traditional medicine. The focus of interest here is a specific group of secondary plant substances: the curcuminoids, of which curcumin is the best known and best studied.

Origin and tradition

Turmeric belongs to the ginger family and originally comes from South Asia. The rootstock (rhizome) of the plant is used.

  • Spice: The rhizome is dried and ground into the bright yellow powder that we know as turmeric. It is an indispensable ingredient in many curry mixtures.
  • Traditional use: In Ayurveda and Traditional Chinese Medicine (TCM), turmeric has been used for thousands of years, mainly due to its properties as described in the respective traditional teachings.

What is curcumin?

Curcumin is the main representative of the so-called curcuminoids and the ingredient responsible for the intense yellow color of turmeric powder. It usually only makes up around 2 to 5 percent of the dried turmeric rhizome.

Curcumin has attracted considerable attention in scientific research in recent decades. Studies, often in the laboratory (in vitro) or on animals, investigate a variety of molecular mechanisms, including medical applications, that may be associated with curcumin. 1

Turmeric in the kitchen

Turmeric is a mild, slightly bitter and earthy tasting spice. It not only gives dishes an appetizing color, but also a delicate aroma.

  • Bioavailability: An important topic is the so-called bioavailability of curcumin. This means how well the human body can absorb the substance. In its pure form, curcumin is poorly absorbed into the bloodstream via the intestine. A key problem with turmeric powder is its low solubility, poor intestinal permeability, instability at alkaline pH or rapid metabolism. These factors contribute to the low bioavailability of curcumin, which limits its potential for oral administration. In recent years, various formulations of dietary supplements have been increasingly developed to address these problems and thus enable significantly better bioavailability. (2, 15, 16)
  • Tip for the kitchen: To improve absorption, turmeric is traditionally often used in Indian cuisine in combination with fat (oil) and black pepper. The ingredient piperine from the pepper can increase the bioavailability of curcumin in the body.

Current research

Research on turmeric and curcumin in particular is very active. Scientists are continuously investigating the role curcumin could play in various biological processes.3-14,17

Important: Most of the promising results come from basic research and clinical studies on humans are still ongoing or in early phases. It is crucial to always view the results of research critically and not to transfer them prematurely to everyday human life.

Referenzen

  1. Akaberi M, Sahebkar A, Emami SA. Turmeric and Curcumin: From Traditional to Modern Medicine. Adv Exp Med Biol. 2021;1291:15-39.
  2. Jamwal R. Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers. J Integr Med. 2018;16(6):367-74.
  3. Dehzad MJ, Ghalandari H, Nouri M, Askarpour M. Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Cytokine. 2023;164:156144.
  4. Kou H, Huang L, Jin M, He Q, Zhang R, Ma J. Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis. Front Immunol. 2023;14:1121655.
  5. Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Nutrients. 2019;11(8).
  6. Panknin TM, Howe CL, Hauer M, Bucchireddigari B, Rossi AM, Funk JL. Curcumin Supplementation and Human Disease: A Scoping Review of Clinical Trials. Int J Mol Sci. 2023;24(5).
  7. Zia A, Farkhondeh T, Pourbagher-Shahri AM, Samarghandian S. The role of curcumin in aging and senescence: Molecular mechanisms. Biomed Pharmacother. 2021;134:111119.
  8. Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, et al. Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial. Front Immunol. 2022;13:891822.
  9. Zeng L, Yu G, Hao W, Yang K, Chen H. The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. Biosci Rep. 2021;41(6).
  10. Marton LT, Pescinini ESLM, Camargo MEC, Barbalho SM, Haber J, Sinatora RV, et al. The Effects of Curcumin on Diabetes Mellitus: A Systematic Review. Front Endocrinol (Lausanne). 2021;12:669448.
  11. Moradi Baniasadi M, Arzhang P, Setayesh A, Moradi M, Nasli-Esfahani E, Azadbakht L. The effect of turmeric/curcumin supplementation on anthropometric indices in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Diabetes. 2025;15(1):34.
  12. Jafari-Nozad AM, Jafari A, Zangooie A, Behdadfard M, Zangouei AS, Aschner M, et al. Curcumin Combats against Gastrointestinal Cancer: A Review of Current Knowledge Regarding Epigenetics Mechanisms with a Focus on DNA Methylation. Curr Med Chem. 2023;30(38):4374-88.
  13. Francis AJ, Sreenivasan C, Parikh A, AlQassab O, Kanthajan T, Pandey M, et al. Curcumin and Cognitive Function: A Systematic Review of the Effects of Curcumin on Adults With and Without Neurocognitive Disorders. Cureus. 2024;16(8):e67706.
  14. Liu X, Lin L, Hu G. Meta-analysis of the effect of curcumin supplementation on skeletal muscle damage status. PLoS One. 2024;19(7):e0299135.
  15. Schiborr C, Kocher A, Behnam D, Jandasek J, Toelstede S, Frank J. The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res. 2014;58(3):516-27.
  16. Hegde M, Girisa S, BharathwajChetty B, Vishwa R, Kunnumakkara AB. Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far? ACS Omega. 2023;8(12):10713-46.
  17. Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res. 2018;32(6):985-95.

Disclaimer

Disclaimer: This article is for information purposes only and in no way replaces the advice of a doctor or pharmacist. If you have any health complaints, please always consult a healthcare professional.